The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling.

ABSTRACT:

Unlabelled

Our laboratory showed that overexpression of fibroblast growth factor-2 (FGF2) protected the heart against ischemia-reperfusion injury. FGF2 has different protein isoforms (low [LMW] and high [HMW] molecular weight isoforms) produced from alternative translation start sites. However, which FGF2 isoform(s) mediates this cardioprotection, and which signaling pathway (i.e., mitogen-activated protein kinase (MAPK)) elicits FGF2 isoform-induced cardioprotection remains to be elucidated.

Methods and results

Wildtype, Fgf2 KO (absence of all FGF2 isoforms) and FGF2 LMWKO (absence of LMW isoform) hearts were subjected to an ex vivo work-performing heart ischemic model of 60 min ischemia and 120 min reperfusion. There was a significant decrease in the recovery of post-isch

SUBMITTER: Liao S 

PROVIDER: S-EPMC1852491 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature