Expression of calcitonin receptor-like receptor in human vascular tumours.

ABSTRACT:

Background

Vascular tumours such as Kaposi's sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.

Aim

To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.

Methods

CRLR expression was investigated in several specimens of Kaposi's sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.

Results

Intense and specific CRLR-immunoreact

SUBMITTER: Hagner S 

PROVIDER: S-EPMC1861761 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature