Differential expression and distribution of epithelial adhesion molecules in non-small cell lung cancer and normal bronchus.

ABSTRACT:

Background

Changes in epithelial cell interactions have been implicated in carcinogenesis, tumour invasion and metastasis.

Aim

To screen for altered expression of epithelial adhesion genes in lung cancer development.

Methods

Gene expression profiles were assessed with cDNA expression arrays in eight non-small cell lung cancer (NSCLC) and eight normal bronchi obtained from the same patient. Immunohistochemistry (IHC) and RNA in situ hybridisation (ISH) were used to confirm the most prominently expressed adhesion molecules and to investigate their distribution at protein and mRNA levels.

Results

43 differentially expressed cancer-related genes were identified in adenocarcinoma, squamous cell carcinoma (SCC) and normal bronchus. Five of these genes are related to

SUBMITTER: Boelens MC 

PROVIDER: S-EPMC1955047 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature