Ontology highlight
ABSTRACT:
SUBMITTER: d'Abbadie M
PROVIDER: S-EPMC1978225 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Nature biotechnology 20070715 8
In the absence of repair, lesions accumulate in DNA. Thus, DNA persisting in specimens of paleontological, archaeological or forensic interest is inevitably damaged. We describe a strategy for the recovery of genetic information from damaged DNA. By molecular breeding of polymerase genes from the genus Thermus (Taq (Thermus aquaticus), Tth (Thermus thermophilus) and Tfl (Thermus flavus)) and compartmentalized self-replication selection, we have evolved polymerases that can extend single, double ...[more]