Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors.

ABSTRACT: The mechanism of lineage commitment from hematopoietic stem cells (HSCs) is not well understood. Although commitment to either the lymphoid or the myeloid lineage is popularly viewed as the first step of lineage restriction from HSCs, this model of hematopoietic differentiation has recently been challenged. The previous identification of multipotent progenitors (MPPs) that can produce lymphocytes and granulocyte/macrophages (GMs) but lacks erythroid differentiation ability suggests the existence of an alternative HSC differentiation program. Contribution to different hematopoietic lineages by these MPPs under physiological conditions, however, has not been carefully examined. In this study, we performed a refined characterization of MPPs by subfractionating three distinct subsets based on

SUBMITTER: Lai AY 

PROVIDER: S-EPMC2118384 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature