The impact of pre-exposure prophylaxis (PrEP) on HIV epidemics in Africa and India: a simulation study.

ABSTRACT:

Background

Pre-exposure prophylaxis (PrEP) is a promising new HIV prevention method, especially for women. An urgent demand for implementation of PrEP is expected at the moment efficacy has been demonstrated in clinical trials. We explored the long-term impact of PrEP on HIV transmission in different HIV epidemics.

Methodology/principal findings

We used a mathematical model that distinguishes the general population, sex workers and their clients. PrEP scenarios varying in effectiveness, coverage and target group were modeled in the epidemiological settings of Botswana, Nyanza Province in Kenya, and Southern India. We also studied the effect of condom addition or condom substitution during PrEP use. Main outcome was number of HIV infections averted over ten years of PrEP use.

SUBMITTER: Vissers DC 

PROVIDER: S-EPMC2367053 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature