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Interactions between dendritic cells and CD4+ T cells during Plasmodium infection.

ABSTRACT:

Background

During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells.

Methods

Using a mouse malaria model, the interactions of DCs and naïve CD4+ T cells have been analysed.

Results

DCs, either incubated in vitro with infected erythrocytes or isolated from infected mice, are able to present exogenous antigens by MHC-II, but are not able to establish prolonged effective interactions with naïve CD4+ T cells and do not induce T cell activation. It was also found that effective T cell activation of naïve CD4+ T cells is impaired during late Plasmodium yoelii infection.

Conclusion

These data may provide a mechanism for the lack of effective adaptive immune responses induced by the Plasmodium parasite.

SUBMITTER: Ocana-Morgner C

PROVIDER: S-EPMC2423365 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature

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Interactions between dendritic cells and CD4+ T cells during Plasmodium infection.

Ocaña-Morgner Carlos C Wong Kurt A KA Rodriguez Ana A

Malaria journal 20080521

<h4>Background</h4>During infection, dendritic cells (DCs) encounter pathogenic microorganisms that can modulate their function and shape the T cell responses generated. During the process of T cell activation, DCs establish strong, long-lasting interactions with naïve T cells.<h4>Methods</h4>Using a mouse malaria model, the interactions of DCs and naïve CD4+ T cells have been analysed.<h4>Results</h4>DCs, either incubated in vitro with infected erythrocytes or isolated from infected mice, are a ...[more]

PMID: 18495039

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