Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC2525596 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20080714 8
In mantle cell lymphoma (MCL) and some cases of multiple myeloma (MM), cyclin D1 expression is deregulated by chromosome translocations involving the immunoglobulin heavy chain (IgH) locus. To evaluate the mechanisms responsible, gene targeting was used to study long-distance gene regulation. Remarkably, these targeted cell lines lost the translocated chromosome (t(11;14)). In these MCL and MM cells, the nonrearranged cyclin D1 (CCND1) locus reverts from CpG hypomethylated to hypermethylated. Re ...[more]