Dataset Information

Vitamin K, circulating cytokines, and bone mineral density in older men and women.

ABSTRACT:

Background

Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro.

Objective

The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein (CRP) concentrations and 2) the effect of daily 500 mug phylloquinone supplementation for 3 y on cytokine concentrations.

Design

Concentrations of IL-6, osteoprotegerin, and CRP and bone mineral density (BMD) were measured at baseline and after 3 y of follow-up in 379 healthy men and women (60-81 y; 58.5% women) participating in a randomized trial that studied the effect of vitamin K supplementation on bone loss.

Results

Cross-sectionally, plasma phylloquinone was inversely associated with IL-6 and CRP, whereas serum %ucOC was inversely associated with IL-6. Osteoprotegerin was associated positively with plasma phylloquinone and inversely with %ucOC. No differences were observed in the 3-y change in IL-6, osteoprotegerin, and CRP concentrations between participants who received phylloquinone supplementation and those who did not. Overall, no association was observed between the 3-y changes in circulating cytokines and BMD.

Conclusions

Poor vitamin K status was associated with high concentrations of cytokines involved in bone turnover, but vitamin K supplementation did not confer a decrease in cytokine concentrations. The healthy status of this cohort may explain a lack of effect of vitamin K supplementation on cytokine concentrations. This trial was registered with www.clinicaltrials.gov as NCT00183001.

SUBMITTER: Shea MK

PROVIDER: S-EPMC2532855 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Publications

Vitamin K, circulating cytokines, and bone mineral density in older men and women.

Shea M Kyla MK Dallal Gerard E GE Dawson-Hughes Bess B Ordovas José M JM O'Donnell Christopher J CJ Gundberg Caren M CM Peterson James W JW Booth Sarah L SL

The American journal of clinical nutrition 20080801 2

<h4>Background</h4>Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro.<h4>Objective</h4>The objective of this study was to assess 1) associations between measures of vitamin K status [plasma phylloquinone and serum percentage of undercarboxylated osteocalcin (%ucOC)] and IL-6, osteoprotegerin, and C-reactive protein (CRP) concentrations and 2) the effect of daily 500 mug phylloquinone supplementation for 3 y on cytokine concentrat ...[more]

PMID: 18689371

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Dataset Information

Vitamin K, circulating cytokines, and bone mineral density in older men and women.

Background

Objective

Design

Results

Conclusions

Publications

Vitamin K, circulating cytokines, and bone mineral density in older men and women.

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