Prognostic significance of VEGF expression in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy.

ABSTRACT:

Background

The prediction of response to treatment would be valuable for managing cervical carcinoma with neoadjuvant chemotherapy.

Methods

To this end, the expression of VEGF was analyzed by immunohistochemistry using paraffin-embedded pre-treatment cervical biopsy tissues. This study included 29 patients with bulky IB to IIA cervical squamous cell carcinoma treated with neoadjuvant chemotherapy.

Results

Fifteen (51.7%) of 29 patients were scored as VEGF-positive. Response to chemotherapy (complete response or residual tumor with less than 3 mm stromal invasion) was observed in eight patients (27.6%), and it was negatively associated with VEGF expression (P = 0.009). With logistic regression analysis, VEGF positivity continued to be an independent predictor for poor

SUBMITTER: Choi CH 

PROVIDER: S-EPMC2572070 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature