Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of myasthenia gravis.

ABSTRACT:

Background

About 5% of western populations are afflicted by autoimmune diseases many of which are affected by sex hormones. Autoimmune diseases are complex and involve many genes. Identifying these disease-associated genes contributes to development of more effective therapies. Also, association studies frequently imply genomic regions that contain disease-associated genes but fall short of pinpointing these genes. The identification of disease-associated genes has always been challenging and to date there is no universal and effective method developed.

Results

We have developed a method to prioritize disease-associated genes for diseases affected strongly by sex hormones. Our method uses various types of information available for the genes, but no information that directly

SUBMITTER: Kaur M 

PROVIDER: S-EPMC2592250 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature