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Media ion composition controls regulatory and virulence response of Salmonella in spaceflight.


ABSTRACT: The spaceflight environment is relevant to conditions encountered by pathogens during the course of infection and induces novel changes in microbial pathogenesis not observed using conventional methods. It is unclear how microbial cells sense spaceflight-associated changes to their growth environment and orchestrate corresponding changes in molecular and physiological phenotypes relevant to the infection process. Here we report that spaceflight-induced increases in Salmonella virulence are regulated by media ion composition, and that phosphate ion is sufficient to alter related pathogenesis responses in a spaceflight analogue model. Using whole genome microarray and proteomic analyses from two independent Space Shuttle missions, we identified evolutionarily conserved molecular pathways in Salmonella that respond to spaceflight under all media compositions tested. Identification of conserved regulatory paradigms opens new avenues to control microbial responses during the infection process and holds promise to provide an improved understanding of human health and disease on Earth.

SUBMITTER: Wilson JW 

PROVIDER: S-EPMC2592540 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

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Media ion composition controls regulatory and virulence response of Salmonella in spaceflight.

Wilson James W JW   Ott C Mark CM   Quick Laura L   Davis Richard R   Höner zu Bentrup Kerstin K   Crabbé Aurélie A   Richter Emily E   Sarker Shameema S   Barrila Jennifer J   Porwollik Steffen S   Cheng Pui P   McClelland Michael M   Tsaprailis George G   Radabaugh Timothy T   Hunt Andrea A   Shah Miti M   Nelman-Gonzalez Mayra M   Hing Steve S   Parra Macarena M   Dumars Paula P   Norwood Kelly K   Bober Ramona R   Devich Jennifer J   Ruggles Ashleigh A   CdeBaca Autumn A   Narayan Satro S   Benjamin Joseph J   Goulart Carla C   Rupert Mark M   Catella Luke L   Schurr Michael J MJ   Buchanan Kent K   Morici Lisa L   McCracken James J   Porter Marc D MD   Pierson Duane L DL   Smith Scott M SM   Mergeay Max M   Leys Natalie N   Stefanyshyn-Piper Heidemarie M HM   Gorie Dominic D   Nickerson Cheryl A CA  

PloS one 20081212 12


The spaceflight environment is relevant to conditions encountered by pathogens during the course of infection and induces novel changes in microbial pathogenesis not observed using conventional methods. It is unclear how microbial cells sense spaceflight-associated changes to their growth environment and orchestrate corresponding changes in molecular and physiological phenotypes relevant to the infection process. Here we report that spaceflight-induced increases in Salmonella virulence are regul  ...[more]

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