Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes.

ABSTRACT: Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(-1) of insulin with no significant background secretion.

SUBMITTER: Duan F 

PROVIDER: S-EPMC2592943 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature