Sequence and structural evolution of the KsgA/Dim1 methyltransferase family.

ABSTRACT:

Background

One of the 60 or so genes conserved in all domains of life is the ksgA/dim1 orthologous group. Enzymes from this family perform the same post-transcriptional nucleotide modification in ribosome biogenesis, irrespective of organism. Despite this common function, divergence has enabled some family members to adopt new and sometimes radically different functions. For example, in S. cerevisiae Dim1 performs two distinct functions in ribosome biogenesis, while human mtTFB is not only an rRNA methyltransferase in the mitochondria but also a mitochondrial transcription factor. Thus, these proteins offer an unprecedented opportunity to study evolutionary aspects of structure/function relationships, especially with respect to our recently published work on the binding mode of a K

SUBMITTER: O'Farrell HC 

PROVIDER: S-EPMC2614427 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature