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Synthesis of (-)-hamigeran B.

ABSTRACT: The synthesis of (-)-hamigeran B has been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramolecular C-H insertion of alpha-aryl-alpha-diazoketones. The endo-isopropyl group was installed by selective hydrogenation of a cyclopropylidene substituent.

SUBMITTER: Taber DF

PROVIDER: S-EPMC2626181 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Synthesis of (-)-hamigeran B.

Taber Douglass F DF Tian Weiwei W

The Journal of organic chemistry 20080905 19

The synthesis of (-)-hamigeran B has been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramolecular C-H insertion of alpha-aryl-alpha-diazoketones. The endo-isopropyl group was installed by selective hydrogenation of a cyclopropylidene substituent. ...[more]

PMID: 18771326

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