Insertion and deletion events that define the pathogen Mycobacterium avium subsp. paratuberculosis.

ABSTRACT: Mycobacterium avium comprises genetically related yet phenotypically distinct subspecies. Consistent with their common origin, whole-genome sequence comparisons have revealed extensive synteny among M. avium organisms. However, the sequenced strains also display numerous regions of heterogeneity that likely contribute to the diversity of the individual subspecies. Starting from a phylogenetic framework derived by multilocus sequence analysis, we examined the distribution of 25 large sequence polymorphisms across a panel of genetically defined M. avium strains. This distribution was most variable among M. avium subsp. hominissuis isolates. In contrast, M. avium subsp. paratuberculosis strains exhibited a characteristic profile, with all isolates containing a set of genomic insertions absent

SUBMITTER: Alexander DC 

PROVIDER: S-EPMC2632067 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature