Ontology highlight
ABSTRACT:
SUBMITTER: Marintchev A
PROVIDER: S-EPMC2656774 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Cell 20090201 3
The RNA helicase eIF4A plays a key role in unwinding of mRNA and scanning during translation initiation. Free eIF4A is a poor helicase and requires the accessory proteins eIF4G and eIF4H. However, the structure of the helicase complex and the mechanisms of stimulation of eIF4A activity have remained elusive. Here we report the topology of the eIF4A/4G/4H helicase complex, which is built from multiple experimentally observed domain-domain contacts. Remarkably, some of the interactions are continu ...[more]