Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population.

ABSTRACT:

Introduction

Nicotine dependence results from a complex interplay of genetic and environmental factors. Over the past several years, a large number of studies have been performed to identify distinct gene loci containing genetic vulnerability to nicotine dependence. Two of the most prominent studies were conducted by the Collaborative Study of the Genetics of Nicotine Dependence (NICSNP) Consortium using both candidate gene and high-density association approaches.

Methods

We attempted to confirm and extend the most significant findings from the high-density association study and the candidate gene study using the behavioral and genetic resources of the Iowa Adoption Studies, the largest case-control adoption study of substance use in the United States.

Results

We foun

SUBMITTER: Philibert RA 

PROVIDER: S-EPMC2666378 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature