Biological process linkage networks.

ABSTRACT:

Background

The traditional approach to studying complex biological networks is based on the identification of interactions between internal components of signaling or metabolic pathways. By comparison, little is known about interactions between higher order biological systems, such as biological pathways and processes. We propose a methodology for gleaning patterns of interactions between biological processes by analyzing protein-protein interactions, transcriptional co-expression and genetic interactions. At the heart of the methodology are the concept of Linked Processes and the resultant network of biological processes, the Process Linkage Network (PLN).

Results

We construct, catalogue, and analyze different types of PLNs derived from different data sources and different

SUBMITTER: Dotan-Cohen D 

PROVIDER: S-EPMC2669181 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature