Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.
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ABSTRACT:
SUBMITTER: Kolstoe SE
PROVIDER: S-EPMC2669789 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.
Kolstoe Simon E SE Ridha Basil H BH Bellotti Vittorio V Wang Nan N Robinson Carol V CV Crutch Sebastian J SJ Keir Geoffrey G Kukkastenvehmas Riitta R Gallimore J Ruth JR Hutchinson Winston L WL Hawkins Philip N PN Wood Stephen P SP Rossor Martin N MN Pepys Mark B MB
Proceedings of the National Academy of Sciences of the United States of America 20090416 18
New therapeutic approaches in Alzheimer's disease are urgently needed. The normal plasma protein, serum amyloid P component (SAP), is always present in cerebrospinal fluid (CSF) and in the pathognomonic lesions of Alzheimer's disease, cerebrovascular and intracerebral Abeta amyloid plaques and neurofibrillary tangles, as a result of its binding to amyloid fibrils and to paired helical filaments, respectively. SAP itself may also be directly neurocytotoxic. Here, in this unique study in Alzheimer ...[more]
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