Transcriptional profiling with a pathway-oriented analysis identifies dysregulated molecular phenotypes in the endometrium of patients with polycystic ovary syndrome.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic oligo/anovulation, hyperandrogenemia, infertility, and metabolic alterations related to insulin resistance. These abnormalities in PCOS may have complex effects on pathophysiology of the endometrium, contributing to infertility and endometrial disorders.

Objective

The objective of this study was to examine dysregulated signaling pathways in the endometrium of patients with PCOS (PCOSE) by analyzing expression profiles with a pathway-oriented method.

Design

Microarrays, RT-PCR, laser capture microdissection, and immunohistochemistry were performed with endometrial tissues.

Setting

This study was performed at a university hospital laboratory.

Patients

This stud

SUBMITTER: Kim JY 

PROVIDER: S-EPMC2682468 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature