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Identifying protein-coding genes in genomic sequences.


ABSTRACT: The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets.

SUBMITTER: Harrow J 

PROVIDER: S-EPMC2687780 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Identifying protein-coding genes in genomic sequences.

Harrow Jennifer J   Nagy Alinda A   Reymond Alexandre A   Alioto Tyler T   Patthy Laszlo L   Antonarakis Stylianos E SE   Guigó Roderic R  

Genome biology 20090130 1


The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets. ...[more]

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