Differences in resistance mutations among HIV-1 non-subtype B infections: a systematic review of evidence (1996-2008).

ABSTRACT: Ninety percent of HIV-1-infected people worldwide harbour non-subtype B variants of HIV-1. Yet knowledge of resistance mutations in non-B HIV-1 and their clinical relevance is limited. Although a few reviews, editorials and perspectives have been published alluding to this lack of data among non-B subtypes, no systematic review has been performed to date.With this in mind, we conducted a systematic review (1996-2008) of all published studies performed on the basis of non-subtype B HIV-1 infections treated with antiretroviral drugs that reported genotype resistance tests. Using an established search string, 50 studies were deemed relevant for this review.These studies reported genotyping data from non-B HIV-1 infections that had been treated with either reverse transcriptase inhibitors or p

SUBMITTER: Martinez-Cajas JL 

PROVIDER: S-EPMC2713201 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature