Evaluation of expression and function of the H+/myo-inositol transporter HMIT.

ABSTRACT:

Background

The phosphoinositide (PIns) signalling pathway regulates a series of neuronal processes, such as neurotransmitter release, that are thought to be altered in mood disorders. Furthermore, mood-stabilising drugs have been shown to inhibit key enzymes that regulate PIns production and alter neuronal growth cone morphology in an inositol-reversible manner. Here, we describe analyses of expression and function of the recently identified H+/myo-inositol transporter (HMIT) investigated as a potential regulator of PIns signalling.

Results

We show that HMIT is primarily a neuronal transporter widely expressed in the rat and human brain, with particularly high levels in the hippocampus and cortex, as shown by immunohistochemistry. The transporter is localised at the Golgi ap

SUBMITTER: Di Daniel E 

PROVIDER: S-EPMC2717050 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature