Myo-Inositol in Fermented Sugar Matrix Improves Human Macrophage Function.

ABSTRACT:

Scope

Reactive oxygen species production by innate immune cells plays a central role in host defense against invading pathogens at wound-site. A weakened host-defense results in persistent infection leading to wound chronicity. Fermented Papaya Preparation (FPP), a complex sugar matrix, bolsters respiratory burst activity and improves wound healing outcomes in chronic wound patients. The objective of the current study was to identify underlying molecular factor/s responsible for augmenting macrophage host defense mechanisms following FPP supplementation.

Methods and results

In depth LC-MS/MS analysis of cells supplemented with FPP led to identification of myo-inositol as a key determinant of FPP activity towards improving macrophage function. Myo-inositol, in quantities that

SUBMITTER: Ghosh N 

PROVIDER: S-EPMC9420542 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature