High resolution genomic analysis of 18q- using oligo-microarray comparative genomic hybridization (aCGH).

ABSTRACT: The advent of oligonucleotide array comparative genomic hybridization (aCGH) has revolutionized diagnosis of chromosome abnormalities in the genetics clinic. This new technology also has valuable potential as a research tool to investigate larger genomic rearrangements that are typically diagnosed via routine karyotype. aCGH was used as a tool for the high-resolution analysis of chromosome content in individuals with known deletions of chromosome 18. The aim of this study was to clarify the precise location of the breakpoints as well as to determine the presence of occult translocations creating additional deletions and duplications. One hundred eighty-nine DNA samples from individuals with 18q deletions were analyzed. No breakpoint clusters were identified, as no more than two individuals

SUBMITTER: Heard PL 

PROVIDER: S-EPMC2731576 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature