Ontology highlight
ABSTRACT:
SUBMITTER: Wu RS
PROVIDER: S-EPMC2737688 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Wu Roland S RS Chudasama Neelesh N Zakharov Sergey I SI Doshi Darshan D Motoike Howard H Liu Guoxia G Yao Yongneng Y Niu Xiaowei X Deng Shi-Xian SX Landry Donald W DW Karlin Arthur A Marx Steven O SO
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090701 26
Large-conductance, voltage- and Ca(2+)-gated potassium (BK) channels control excitability in a number of cell types. BK channels are composed of alpha subunits, which contain the voltage-sensor domains and the Ca(2+)- sensor domains and form the pore, and often one of four types of beta subunits, which modulate the channel in a cell-specific manner. beta 4 is expressed in neurons throughout the brain. Deletion of beta 4 in mice causes temporal lobe epilepsy. Compared with channels composed of al ...[more]