Prognostic significance of copy-number alterations in multiple myeloma.

ABSTRACT:

Purpose

Chromosomal aberrations are a hallmark of multiple myeloma but their global prognostic impact is largely unknown.

Patients and methods

We performed a genome-wide analysis of malignant plasma cells from 192 newly diagnosed patients with myeloma using high-density, single-nucleotide polymorphism (SNP) arrays to identify genetic lesions associated with prognosis.

Results

Our analyses revealed deletions and amplifications in 98% of patients. Amplifications in 1q and deletions in 1p, 12p, 14q, 16q, and 22q were the most frequent lesions associated with adverse prognosis, whereas recurrent amplifications of chromosomes 5, 9, 11, 15, and 19 conferred a favorable prognosis. Multivariate analysis retained three independent lesions: amp(1q23.3), amp(5q31.3), and del(12p

SUBMITTER: Avet-Loiseau H 

PROVIDER: S-EPMC2754906 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature