Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer.

ABSTRACT:

Context

The established relationship between lymph node metastasis and prognosis in colorectal cancer suggests that recurrence in 25% of patients with lymph nodes free of tumor cells by histopathology (pN0) reflects the presence of occult metastases. Guanylyl cyclase 2C (GUCY2C) is a marker expressed by colorectal tumors that could reveal occult metastases in lymph nodes and better estimate recurrence risk.

Objective

To examine the association of occult lymph node metastases detected by quantifying GUCY2C messenger RNA, using the reverse transcriptase-polymerase chain reaction, with recurrence and survival in patients with colorectal cancer.

Design, setting, and participants

Prospective study of 257 patients with pN0 colorectal cancer enrolled between March 2002 and J

SUBMITTER: Waldman SA 

PROVIDER: S-EPMC2756012 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature