Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience.

ABSTRACT:

Aim

To assess the association between chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in Pakistan, and the genotype distribution among these HCC patients.

Methods

One hundred and sixty-one subjects with HCC were included in this study. Liver biopsy was performed on 145 of the patients; sixteen were excluded because they failed to fulfill the inclusion criteria. Qualitative polymerase chain reaction (PCR) was performed for hepatitis B virus and HCV. Samples positive for HCV RNA were genotyped using genotype-specific PCR and confirmed by HCV 5' noncoding region sequencing analysis.

Results

Chronic HCV infection was identified a major risk factor (63.44% of tested HCC patients) for the development of HCC. The time from HCV infection to appear

SUBMITTER: Idrees M 

PROVIDER: S-EPMC2768888 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature