Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer.

ABSTRACT:

Background

The malignant potential of serous ovarian tumors, the most common ovarian tumor subtype, varies from benign to low malignant potential (LMP) tumors to frankly invasive cancers. Given the uncertainty about the relationship between these different forms, we compared their patterns of gene expression.

Methods

Expression profiling was carried out on samples of 7 benign, 7 LMP and 28 invasive (moderate and poorly differentiated) serous tumors and four whole normal ovaries using oligonucleotide microarrays representing over 21,000 genes.

Results

We identified 311 transcripts that distinguished invasive from benign tumors, and 20 transcripts that were significantly differentially expressed between invasive and LMP tumors at p < 0.01 (with multiple testing correcti

SUBMITTER: Merritt MA 

PROVIDER: S-EPMC2770078 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature