Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk.

ABSTRACT:

Objective

Whereas epidemiological studies show that levels of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) predict incident cardiovascular disease (CVD), there is limited evidence relating lipoprotein subfractions and composite measures of subfractions to risk for CVD in prospective cohort studies.

Methods and results

We tested whether combinations of lipoprotein subfractions independently predict CVD in a prospective cohort of 4594 initially healthy men and women (the Malmö Diet and Cancer Study, mean follow-up 12.2 years, 377 incident cardiovascular events). Plasma lipoproteins and lipoprotein subfractions were measured at baseline with a novel high-resolution ion mobility technique. Principal component analysis (PCA) of subf

SUBMITTER: Musunuru K 

PROVIDER: S-EPMC2772123 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature