Ontology highlight
ABSTRACT:
SUBMITTER: Rhodes J
PROVIDER: S-EPMC2772726 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20090824 21
A growing body of evidence indicates that early mitotic inhibitor 1 (Emi1) is essential for genomic stability, but how this function relates to embryonic development and cancer pathogenesis remains unclear. We have identified a zebrafish mutant line in which deficient emi1 gene expression results in multilineage hematopoietic defects and widespread developmental defects that are p53 independent. Cell cycle analyses of Emi1-depleted zebrafish or human cells showed chromosomal rereplication, and m ...[more]