Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I.

ABSTRACT:

Background

The allochimeric MHC class I molecule [alpha1h1/u]-RT1.Aa that contains donor-type (Wistar Furth, WF; RT1u) epitopes displayed on recipient-type (ACI, RT1a) administered in conjunction with sub-therapeutic dose of cyclosporine (CsA) induces indefinite survival of heterotopic cardiac allografts in rat model. In vascularized transplantation models, the spleen contributes to graft rejection by generating alloantigen reactive T cells. The immune response in allograft rejection involves a cascade of molecular events leading to the formation of immunological synapses between T cells and the antigen-presenting cells.

Methodology/principal findings

To elucidate the molecular pathways involved in the immunosuppressive function of allochimeric molecule we performed microarr

SUBMITTER: Lisik W 

PROVIDER: S-EPMC2780702 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature