Time to seizure occurrence and damage in PROFILE, a multi-ethnic systemic lupus erythematosus cohort.

ABSTRACT: The objective of this study was to determine risk factors predicting seizures and damage caused by seizures in a multi-ethnic systemic lupus erythematosus cohort (PROFILE) that includes systemic lupus erythematosus patients (n = 1295) from five different US institutions. Only patients with seizures after systemic lupus erythematosus diagnosis (incident) were included in the analyses of clinical seizures (80/1295, 6.2%), but all patients (prevalent and incident) were included in the analyses of damage caused by seizures (51/1295, 3.9%). We examined socioeconomic-demographic, clinical, and genetic variables predictive of clinical seizures and damage from seizures by Cox proportional hazard ratios (HR) and 95% confidence intervals (CI). Independent predictors of a shorter time to the occurren

SUBMITTER: Ramsey-Goldman R 

PROVIDER: S-EPMC2787620 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature