Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis).

ABSTRACT: The major histocompatibility complex (MHC) class I B gene/allelic repertoire was investigated in a pedigreed population of cynomolgus macaques of mixed Indonesian/Malaysian origin. The Mafa-B alleles detected in this cohort are mostly specific for a given geographic area, and only a small number of alleles appears to be shared with other populations. This suggests the fast evolution of Mafa-B alleles due to adaptation to new environments. In contrast to humans, the B locus in Old World monkeys displays extensive copy number variation. The Mafa-B and previously defined -A gene combinations segregate in families and thus allowed the definition of extended haplotypes. In many cases it was possible to assign a particular Mafa-I allele to one of these Mafa-A/B haplotypes as well. The presence o

SUBMITTER: Otting N 

PROVIDER: S-EPMC2802488 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature