Variation in the FGFR2 gene and the effect of a low-fat dietary pattern on invasive breast cancer.

ABSTRACT:

Background

The Women's Health Initiative dietary modification (DM) trial provided suggestive evidence of a benefit of a low-fat dietary pattern on breast cancer risk, with stronger evidence among women whose baseline diet was high in fat. Single nucleotide polymorphisms (SNP) in the FGFR2 gene relate strongly to breast cancer risk and could influence intervention effects.

Methods

All 48,835 trial participants were postmenopausal and ages 50 to 79 years at enrollment (1993-1998). We interrogated eight SNPs in intron 2 of the FGFR2 gene for 1,676 women who developed breast cancer during trial follow-up (1993-2005). Case-only analyses were used to estimate odds ratios for the DM intervention in relation to SNP genotype.

Results

Odds ratios for the DM intervention did not

SUBMITTER: Prentice RL 

PROVIDER: S-EPMC2806599 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature