Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.

ABSTRACT:

Objectives

Suicidal ideation is an uncommon but worrisome symptom than can emerge during antidepressant treatment. We have described earlier the association between treatment-emergent suicidal ideation (TESI) and markers in genes encoding glutamate receptor subunits GRIK2 and GRIA3. The present genome-wide association study was conducted to identify additional genetic markers associated with TESI that may help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, and/or specialty care.

Methods

A clinically representative cohort of outpatients with nonpsychotic major depressive disorder enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were treated with citalopram under a standard protocol for up

SUBMITTER: Laje G 

PROVIDER: S-EPMC2819190 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature