DNA methylation profiles of ovarian epithelial carcinoma tumors and cell lines.

ABSTRACT:

Background

Epithelial ovarian carcinoma is a significant cause of cancer mortality in women worldwide and in the United States. Epithelial ovarian cancer comprises several histological subtypes, each with distinct clinical and molecular characteristics. The natural history of this heterogeneous disease, including the cell types of origin, is poorly understood. This study applied recently developed methods for high-throughput DNA methylation profiling to characterize ovarian cancer cell lines and tumors, including representatives of three major histologies.

Methodology/principal findings

We obtained DNA methylation profiles of 1,505 CpG sites (808 genes) in 27 primary epithelial ovarian tumors and 15 ovarian cancer cell lines. We found that the DNA methylation profiles of ova

SUBMITTER: Houshdaran S 

PROVIDER: S-EPMC2825254 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature