Utility of various functional and anatomic imaging modalities for detection of ectopic adrenocorticotropin-secreting tumors.

ABSTRACT:

Context

Because ectopic ACTH-secreting (EAS) tumors are often occult, improved imaging is needed.

Objective

Our objective was to evaluate the utility of [(111)In-DTPA-d-Phe]pentetreotide scintigraphy [octreotide (OCT)] imaging at 6 mCi [low OCT (LOCT)] and 18 mCi [high OCT (HOCT)], [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) and [(18)F]l-3,4-dihydroxyphenylalanine (F-DOPA)-PET scans, computed tomography (CT), and magnetic resonance imaging (MRI).

Design and setting

The study was a prospective evaluation at a clinical research center.

Patients

Forty-one subjects participated, 30 (17 female) with resected EAS tumors and 11 (three female) with occult EAS, based on inferior petrosal sinus sampling results and imaging studies.

Intervention<

SUBMITTER: Zemskova MS 

PROVIDER: S-EPMC2841535 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature