Ontology highlight
ABSTRACT:
SUBMITTER: Kale SP
PROVIDER: S-EPMC2845523 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Kale Shubha P SP Milde Lane L Trapp Marisa K MK Frisvad Jens C JC Keller Nancy P NP Bok Jin Woo JW
Fungal genetics and biology : FG & B 20080711 10
The nuclear regulator LaeA has been shown to govern production of multiple secondary metabolites in Aspergillus nidulans and Aspergillus fumigatus. Herein we examine the role of this protein in Aspergillus flavus. Similarly as in other Aspergilli, LaeA had a major effect on A. flavus secondary metabolism where DeltalaeA and over-expression laeA (OE::laeA) strains yielded opposite phenotypes resulting in decreased (increased) secondary metabolite production. The two mutant strains also exhibited ...[more]