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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

ABSTRACT: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

SUBMITTER: Li Y 

PROVIDER: S-EPMC2845930 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Li Yanping Y   Liu Wencheng W   Oo Tinmarla F TF   Wang Lei L   Tang Yi Y   Jackson-Lewis Vernice V   Zhou Chun C   Geghman Kindiya K   Bogdanov Mikhail M   Przedborski Serge S   Beal M Flint MF   Burke Robert E RE   Li Chenjian C  

Nature neuroscience 20090607 7

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutic  ...[more]

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