Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm.

ABSTRACT:

Objective

Apolipoprotein E (ApoE) genotype has been associated with systemic inflammation and athero-thrombosis however the association with abdominal aortic aneurysm (AAA) has not been previously examined. We assessed the association between ApoE genotype with AAA presence and growth, and serum C-reactive protein (CRP).

Methods

Serum concentrations of CRP (in 1358 men) and 6 single nucleotide polymorphisms (SNPs) for ApoE (in 1711 men) were examined in subjects from the Health In Men Study. 640 men with small AAAs were followed by ultrasound surveillance for a mean of 4.1 years.

Results

There was no association between ApoE genotype and AAA presence. Men heterozygote for the ApoE p.Arg176Cys polymorphism had slower AAA growth, odds ratio for AAA progression> or =medi

SUBMITTER: Golledge J 

PROVIDER: S-EPMC2846218 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature