Proteomics

Dataset Information

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Abdominal aortic aneurysm (AAA) proteomics

ABSTRACT: An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy is currently available to prevent AAA progression, as no drug has been proven effective. Diabetes is a major risk factor for cardiovascular disease in general. However, many studies over the last decade show that type 2 diabetes patients have a lower incidence of AAA and a slower aneurysm growth rate, which has been correlated with metformin use. We performed a proteomics analysis on resected aortic tissue from controls, non-diabetic (ND) and diabetic (D) AAA patients.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cardiovascular System Endothelium, Aorta Endothelium

DISEASE(S): Aortic Aneurysm

SUBMITTER: Thang Pham  

LAB HEAD: Connie Jimenez

PROVIDER: PXD067859 | Pride | 2025-09-29

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Peptide_table.xlsx Xlsx
Protein_table.xlsx Xlsx
Sample_labeling.xlsx Xlsx
Search_Compressed_zipped_Folder.zip Other
TIM_4625_2025-04-14_S1-A5_250414_OPL0000_HeLa50ng_05.d.zip Other
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Publications

Proteome Differences in Smooth Muscle Cells from Diabetic and Non-Diabetic Abdominal Aortic Aneurysm Patients Reveal Metformin-Induced Mechanisms.

van Merrienboer Tara A R TAR   Rombouts Karlijn B KB   van Wijk Albert C W A ACWA   Knol Jaco C JC   Pham Thang V TV   Piersma Sander R SR   Jimenez Connie R CR   Balm Ron R   Yeung Kak K KK   de Waard Vivian V  

Medical sciences (Basel, Switzerland) 20250910 3

<b>Aims</b>: Surgery remains the only definitive treatment option for abdominal aortic aneurysms (AAA), as no conclusive evidence supports drug effectiveness in preventing AAA growth. Although type 2 diabetes (T2D) is an important cardiovascular risk factor, patients with T2D show reduced AAA presence and growth, associated with metformin use. We aimed to investigate the potential benefits of metformin on AAA using proteomics and in vitro experiments. <b>Methods</b>: Proteomics analysis using ta  ...[more]

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