Proteomics

Dataset Information

0

Human adventitial and medial layers from AAA aorta LC-MS/MS

ABSTRACT: Abdominal aortic aneurysm (AAA) is an asymptomatic chronic disease of the aorta and its evolution is unpredictable. Despite the existence of a number of pathological mechanisms contributing to the dilation of the human AAA wall, there is currently no specific therapy to prevent the fatal rupture of the aorta. Our objective was to identify novel mediators and/or biomarkers involved in the instability of the aortic wall that could help to prevent AAA progression.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Abdominal Aorta

DISEASE(S): Abdominal Aortic Aneurysm

SUBMITTER: Estefanía Núñez  

LAB HEAD: Jesús Vázquez

PROVIDER: PXD056789 | Pride | 2025-07-14

REPOSITORIES: pride

Json Xml

Dataset's files

Source:
Action DRS
TMT1_ADVENTICIA_FR_ALL.mzML Mzml
TMT1_ADVENTICIA_FR_ALL.raw Raw
TMT2_ADVENTICIA_FR_ALL.mzML Mzml
TMT2_ADVENTICIA_FR_ALL.raw Raw
TMT3_F1_EN.mzML Mzml
Items per page:
1 - 5 of 25
altmetric image

Publications

Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics.

Cerro-Pardo Isabel I   Núñez Estefanía E   Picatoste Belén B   Márquez-Gálvez Cristina C   Ortega-Villanueva Lucía L   Raposo-Gutiérrez Irene I   Lindholt Jes S JS   Blanco-Colio Luis Miguel LM   Ramiro Almudena R AR   Vázquez Jesús J   Martín-Ventura José Luis JL  

Journal of translational medicine 20250707 1

<h4>Background</h4>Abdominal aortic aneurysm (AAA) is an asymptomatic chronic disease of the aorta and its evolution is unpredictable. Despite the existence of several pathological mechanisms contributing to the dilation of the human AAA wall, there is currently no specific therapy to prevent the fatal rupture of the aorta. Our objective was to identify novel mediators and/or biomarkers involved in the instability of the aortic wall that could help to prevent AAA progression.<h4>Methods</h4>Mult  ...[more]

Similar Datasets

Transcriptomics IL-27 receptor signaling regulated stress hematopoiesis drives Abdominal Aortic Aneurysm development
2019-10-14 | GSE129881 | GEO
Proteomics Shotgun LC-MS analysis of aorta and liver tissues from WT and Gal-1 KO mice to study the role of Galectin-1 in vascular remodeling in atherosclerosis and abdominal aortic aneurysm
2022-04-04 | PXD024637 | Pride
Transcriptomics Angiotensin II induced aneurysms in male ApoE mice
2010-06-24 | E-GEOD-12591 | biostudies-arrayexpress
Transcriptomics RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues
2023-12-07 | GSE183464 | GEO
Proteomics Cycloastragenol inhibit experimental abdominal aortic aneurysm progression
2022-05-20 | PXD030441 | Pride
Transcriptomics PRDM16 Deficiency in Vascular Smooth Muscle Cells Aggravates Abdominal Aortic Aneurysm
2023-06-08 | GSE222440 | GEO
Transcriptomics Expression data in Abdominal Aortic Aneurysms
2021-01-26 | GSE165470 | GEO
Transcriptomics Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1
2021-11-01 | GSE186865 | GEO
Transcriptomics Comparison of infrarenal and suprarenal sections of mouse ApoE-/- abdominal aorta
2010-05-12 | GSE7006 | GEO
Transcriptomics Murine Abdominal Aortic Aneurysm, PPE Model: Transcriptional Profiling of Sham vs. AAA at Day 7
2014-08-31 | E-GEOD-51227 | biostudies-arrayexpress