Regulatory roles of natural antisense transcripts.

ABSTRACT: Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

SUBMITTER: Faghihi MA 

PROVIDER: S-EPMC2850559 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature