Genetic susceptibility variants for chronic lymphocytic leukemia.

ABSTRACT:

Background

There is strong and consistent evidence that a genetic component contributes to the etiology of chronic lymphocytic leukemia (CLL). A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL within a European population.

Methods

We evaluated the association of these variants, or variants in linkage disequilibrium with these variants, with CLL risk in an independent sample of 438 CLL cases and 328 controls.

Results

Of these seven single nucleotide polymorphisms (SNP), six had P trend < 0.05 and had estimated odds ratios (OR) that were strikingly comparable to those of the previous study. Associations were seen for rs9378805 [OR, 1.47; 95% confidence intervals (CI), 1.19-1.80; P trend = 0.0003] near IRF4 and

SUBMITTER: Slager SL 

PROVIDER: S-EPMC2852480 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature