Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women.

ABSTRACT:

Context

Several genome-wide association studies (GWAS) have been performed to identify genes contributing to bone mineral density (BMD), typically in samples of elderly women and men.

Objective

The objective of the study was to identify genes contributing to BMD in premenopausal women.

Design

GWAS using the Illumina 610Quad array in premenopausal European-American (EA) women and replication of the top 50 single-nucleotide polymorphisms (SNPs) for two BMD measures in African-American (AA) women.

Subjects

Subjects included 1524 premenopausal EA women aged 20-45 yr from 762 sibships and 669 AA premenopausal women aged 20-44 yr from 383 sibships.

Interventions

There were no interventions.

Main outcome measures

BMD was measured at the lumbar spine and

SUBMITTER: Koller DL 

PROVIDER: S-EPMC2853986 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature