Association between a literature-based genetic risk score and bone mineral density of African American women in Women Health Initiative Study.

ABSTRACT: Genetic risk of low BMD in African American women remains unclear. Based on SNPs discovered from a predominantly Caucasian sample, genetic profile was summarized and was found to be significantly associated with BMD variation in African American women.

Introduction

Osteoporosis is largely under-recognized and undertreated in African-American women, the post-fracture morbidity and mortality rates in this racial group is rather high. Since BMD was proved to be highly heritable, based on a comprehensive genome-wide meta-analysis that reported 63 BMD-related single nucleotide polymorphisms (SNPs), we aim to unravel the overall genetic risk for decreased BMD and osteoporosis in African-American women.

Methods

Genotype data of 842 African American women in a Women's Health Initiati

SUBMITTER: Xiao X 

PROVIDER: S-EPMC7176548 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature