Clinical and virological features of Dengue in Vietnamese infants.
Ontology highlight
ABSTRACT: Background
Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised.Methodology/principal findings
This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness.Conclusions/significance
Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis.
SUBMITTER: Chau TN
PROVIDER: S-EPMC2854125 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Clinical and virological features of Dengue in Vietnamese infants.
Chau Tran Nguyen Bich TN Anders Katherine L KL Lien Le Bich le B Hung Nguyen Thanh NT Hieu Lu Thi Minh LT Tuan Nguyen Minh NM Thuy Tran Thi TT Phuong Le Thi le T Tham Nguyen Thi Hong NT Lanh Mai Ngoc MN Farrar Jeremy J JJ Whitehead Stephen S SS Simmons Cameron P CP
PLoS neglected tropical diseases 20100413 4
<h4>Background</h4>Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised.<h4>Methodology/principal findings</h4>This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on cl ...[more]
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2010-10-29 | GSE25001 | GEO
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2010-10-29 | E-GEOD-25001 | biostudies-arrayexpress
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